Environmental, Biochemical and Hematological study in rats exposed to Cadmium Chloride in Drinking Water and the role of Vitamin E and C

Abstract The present study was carried out to determine the synergistic role of vitamin E and C in reducing toxic effects cadmium chloride on some blood parameters (RBC count, Hb concentration, PCV, Total WBC Differential count), as well biochemical which include (Malondialdehyde (MDA), Aspartate aminotransferase(AST), Alanine aminotransferase (ALT), Alkaline phosphatase(ALP), Creatinin, Urea) antioxidants (Superoxidedismutase(SOD), Glutathion-S-transferase(GST), Catalase(CAT). Forty adult male rats were divided into five equal groups. first group left without any treatment (the control group), second given (30mg/L), third simultaneously, fourth fifth chloride, simultaneously. results showed a significant decrease (P <0.05) PCV) increase count (neutrophils eosinophils). On other hand, also an concentration (ALT, AST, ALP, Urea, Creatinine, MDA)and antioxidants(SOD, CAT, GST) (T 1 ) compared with group. noticeable improvement studied when using alone or together this indicates therapeutic played by vitamins toxicity caused